反应详情

A mixture of 1.00 g of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 1.10 g of 2-methylpiperazine and 10 ml of pyridine was heated for 15 minutes under reflux. The reaction mixture was evaporated and methanol was added to the residue. The precipitate was filtered and recrystallized from ethanol to give 0.36 g of the title compound as colorless needles, M.p. 239°-240.5° C.

1. temperaturewas heated for 15 minutes
2. temperatureunder reflux
3. customThe reaction mixture was evaporated
4. additionmethanol was added to the residue
5. filtrationThe precipitate was filtered
6. customrecrystallized from ethanol