反应详情

A mixture of 1.50 g of ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate, 1.50 g of 2-methylpiperazine and 5 ml of pyridine was heated for 3 hours under reflux. The solvent of the reaction mixture was evaporated and the residue was dissolved in chloroform. The solution was washed with water, dried and evaporated. The residue was recrystallized from a mixture of benzene and isopropyl ether to give 1.00 g of the title compound as colorless needles, M.p. 126.5°-127.5° C.

1. temperaturewas heated for 3 hours
2. temperatureunder reflux
3. customThe solvent of the reaction mixture was evaporated
4. dissolutionthe residue was dissolved in chloroform
5. washThe solution was washed with water
6. customdried
7. customevaporated
8. customThe residue was recrystallized from a mixture of benzene and isopropyl ether