HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperazine → 6,8-Difluoro-1,4-dihydro-1-isopropyl-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperazine | HCID 66057 | — |
| Reactant | 6,7,8-Trifluoro-1,4-dihydro-1-isopropyl-4-oxoquinoline-3-carboxylic acid | HCID 13477692 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 6,8-Difluoro-1,4-dihydro-1-isopropyl-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid | HCID 13477664 | 48.2% |
Reaction Steps
A mixture of 0.68 g of 6,7,8-trifluoro-1,4-dihydro-1-isopropyl-4-oxoquinoline-3-carboxylic acid, 0.72 g of 2-methyl piperazine and 10 ml of pyridine was treated in the same manner as described for Example 4 to give 0.42 g of the title compound as colorless crystals. M.p. 217°-218° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04528287 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-feb21c015cd5482ba31c36638593dbe1 |
| Source note | uspto-grants-1985_07 |