Methylamine → HCID 20275267, compound

HRID 370726Notes

Reaction equation

HRID 370726 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[N:5]2[N:9]=[N:10][CH:11]=[C:4]2[CH:3]=1.[CH3:12][NH2:13]>O>[CH3:8][C:6]1[N:5]2[N:9]=[N:10][CH:11]=[C:4]2[CH:3]=[C:2]([NH:13][CH3:12])[N:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20275282HCID 20275282, compound

Product 1

HCID 20275267HCID 20275267, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 3.4 g (20 mmole) of 5-chloro-7-methyltriazolo[1,5-c]pyrimidine in 50 ml of water was added 1.25 g (40 mmole) of methylamine as a 40% aqueous solution. The mixture was heated in an oil bath and thickened rapidly as a result. The solid was separated by filtration, and was then recrystallized from a benzene-hexane mixture with treatment with decolorizing charcoal. The product was white needles of 7-methyl-5-(N-methylamino)triazolo[1,5-c]pyrimidine, m.p. 162°-164° C. Analysis: Calculated for C7H9N5 : %C, 51.5; %H, 5.6; %N, 42.9; Found: %C, 51.6; %H, 5.4; %N, 43.1.

Workup

  1. temperatureThe mixture was heated in an oil bath
  2. customThe solid was separated by filtration
  3. customwas then recrystallized from a benzene-hexane mixture with treatment with decolorizing charcoal

Sources & evidence

ORD record
ord-d270d60afac3494d8f263ae54d8a6dfb
Source dataset
uspto-grants-1985_07
Patent number
US04528288

Reaction notes

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