HCID 20275376, compound → HCID 20275386, compound

HRID 370732Notes

Reaction equation

HRID 370732 reaction equation
C([S:4][CH2:5][CH:6]([CH3:20])[C:7]([NH:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=1)[C:15]([O:17][CH3:18])=[O:16])=[O:8])(=O)C.C(SCC(C)C(NC1N=CC=CC=1C(OC)=O)=O)(=O)C>C(Cl)Cl.CO>[SH:4][CH2:5][CH:6]([CH3:20])[C:7]([NH:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=1)[C:15]([O:17][CH3:18])=[O:16])=[O:8]

Participants

4

Reactant 2

HCID 20275376HCID 20275376, compoundHCID 20275380HCID 20275380, compound

Product 1

HCID 20275386HCID 20275386, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Following the procedure of Example 2, but substituting an equivalent amount of methyl 5-(2-acetylthiomethyl-propionamido)-nicotinate, obtained as disclosed in Example 12, for methyl 2-(2-acetylthiomethyl-propionamido)-nicotinate and using a mixture of methylene chloride/methanol 99:1 as eluent for the chromatographic column, methyl 5-(2-mercaptomethyl-propionamido)-nicotinate is obtained: m.p. 96°-97° C., from ethyl acetate.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-42ec96d449c84a6c94b1137f824e2b53
Source dataset
uspto-grants-1985_07
Patent number
US04528296

Reaction notes

Loading…