HCID 20275365, compound → HCID 10448460, compound

HRID 370739Notes

Reaction equation

HRID 370739 reaction equation
C([S:4][CH2:5][CH:6]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:7]([NH:9][C:10]1[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=1)[C:13]([O:15]C)=[O:14])=[O:8])(=O)C.C(SCC(C)C(NC1N=CC=CC=1C(OC)=O)=O)(=O)C>>[SH:4][CH2:5][CH:6]([CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:7]([NH:9][C:10]1[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=1)[C:13]([OH:15])=[O:14])=[O:8]

Participants

3

Reactant 2

HCID 20275365HCID 20275365, compoundHCID 20275380HCID 20275380, compound

Product 1

HCID 10448460HCID 10448460, compound

Procedure

Following the procedure of Example 3, but substituting an equivalent amount of methyl 2-(2-acetylthiomethyl-3-phenyl-propionamido)-isonicotinate, obtained as disclosed in Example 27, for methyl 2-(2-acetylthiomethyl-propionamido)-nicotinate and purifying by chromatography on silica gel column, eluting with methylene chloride/methanol 95:5; 2-(2-mercaptomethyl-3-phenyl-propionamido)-isonicotinic acid is obtained; m.p. 234°-236° C., from absolute ethanol.

Workup

  1. customobtained
  2. custompurifying by chromatography on silica gel column
  3. washeluting with methylene chloride/methanol 95:5

Sources & evidence

ORD record
ord-d37e6879bd5742a68efc4b1503e3923e
Source dataset
uspto-grants-1985_07
Patent number
US04528296

Reaction notes

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