HCID 20275365, compound → HCID 10448460, compound

Participants

Reaction Steps

Following the procedure of Example 3, but substituting an equivalent amount of methyl 2-(2-acetylthiomethyl-3-phenyl-propionamido)-isonicotinate, obtained as disclosed in Example 27, for methyl 2-(2-acetylthiomethyl-propionamido)-nicotinate and purifying by chromatography on silica gel column, eluting with methylene chloride/methanol 95:5; 2-(2-mercaptomethyl-3-phenyl-propionamido)-isonicotinic acid is obtained; m.p. 234°-236° C., from absolute ethanol.

Provenance & Evidence