HRID3708

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)C(NC(=O)c1ccccc1SSc1ccccc1C(=O)NC(C(=O)OC(C)(C)C)c1ccccc1)c1ccccc1

HCID76120819

未命名化合物

PRODUCTS

生成物

结构：O=C(NC(C(=O)O)c1ccccc1)c1ccccc1SSc1ccccc1C(=O)NC(C(=O)O)c1ccccc1

HCID465365

未命名化合物

收率 42.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584099

未命名化合物

PROCEDURE

实验过程

This compound was prepared according to the procedure described in Example 50 using [R-(R*,R*)] (2-{2-[(tert-butoxycarbonyl-phenyl-methyl)-carbamoyl]-phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid tert-butyl ester (0.2 g, 0.3 mmol) from Example 38, 10 mL dichloromethane, and 10 mL trifluoroacetic acid. The crude product was stirred with ether/hexane and filtered to afford 73.0 mg of the title compound, mp 231°-232° C.

WORKUP

后处理

customThis compound was prepared
filtrationfiltered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-90c1ac43b2814299a03384dc402e2956
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05734081
来源说明: uspto-grants-1998_03

反应 SMILES

C([O:5][C:6](=[O:48])[CH:7]([NH:14][C:15](=[O:47])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22][S:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30](=[O:46])[NH:31][CH:32]([C:39]([O:41]C(C)(C)C)=[O:40])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(C)(C)C.ClCCl.FC(F)(F)C(O)=O>CCOCC.CCCCCC>[C:6]([CH:7]([NH:14][C:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22][S:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30]([NH:31][CH:32]([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[C:39]([OH:41])=[O:40])=[O:46])=[O:47])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([OH:48])=[O:5]