Hydrochloric Acid → HCID 178483233, compound

HRID 370807Notes

Reaction equation

HRID 370807 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]2[O:13][C:14]([CH2:17][N:18]([CH3:20])[CH3:19])=[CH:15][CH:16]=2)=[N:5]S(=O)[N:3]=1.[ClH:22]>CO>[OH2:13].[ClH:22].[ClH:22].[ClH:22].[CH3:20][N:18]([CH2:17][C:14]1[O:13][C:12]([CH2:11][S:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])=[CH:16][CH:15]=1)[CH3:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 5384819CHEMBL8982

Product 1

HCID 178483233HCID 178483233, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-amino-4-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide (6.56 g; 20.0 mmoles) [prepared according to published U.K. patent application No. 2,067,987] in 200 mL of methanol was warmed slightly to achieve complete solution, then treated with 13.3 mL of concentrated HCl. After stirring at ambient temperature for 2.5 hours, the solution was concentrated and the residue was triturated with 70 mL of absolute ethanol. The crystals were collected by filtration and dried under vacuum to give 4.3 g (52%) of the title compound, m.p. 166°-169° C. (dec.).

Workup

  1. customprepared
  2. concentrationthe solution was concentrated
  3. customthe residue was triturated with 70 mL of absolute ethanol
  4. filtrationThe crystals were collected by filtration
  5. customdried under vacuum

Sources & evidence

ORD record
ord-443f29472e0f4ef287afb36b8fac1a33
Source dataset
uspto-grants-1985_07
Patent number
US04528375

Reaction notes

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