Hydrochloric Acid → HCID 178478597, compound

HRID 370810Notes

Reaction equation

HRID 370810 reaction equation
[CH2:1]([NH:8][C:9]1[C:13]([NH:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)[CH:20]=2)=[N:12]S(=O)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>CO>[ClH:33].[ClH:33].[ClH:33].[CH2:1]([NH:8][C:9](=[NH:10])[C:13](=[NH:12])[NH:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 233125553-Benzylamino-4-[3-(3-piperidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide

Product 1

HCID 178478597HCID 178478597, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-benzylamino-4-[3-(3-piperidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide (5.14 g; 11.3 mmoles) [prepared according to published U.K. patent application No. 2,067,987] in 100 ml of methanol was treated with 7.55 ml of concentrated HCl. After stirring at ambient temperature for 3 hours, the solution was concentrated and the residue was triturated with acetone, filtered and dried to give 5.16 g (88%) of the title compound, mp 187°-205° C. (dec.).

Workup

  1. customprepared
  2. concentrationthe solution was concentrated
  3. customthe residue was triturated with acetone
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-c51e168699b84acba0a2b017d8647de9
Source dataset
uspto-grants-1985_07
Patent number
US04528375

Reaction notes

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