Hydrochloric Acid → HCID 178478601, compound

HRID 370814Notes

Reaction equation

HRID 370814 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[N:13]=2)=[N:5]S(=O)[N:3]=1.[ClH:26]>>[ClH:26].[ClH:26].[ClH:26].[N:19]1([CH2:18][C:14]2[N:13]=[C:12]([O:11][CH2:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])[CH:17]=[CH:16][CH:15]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 15961340HCID 15961340, compound

Product 1

HCID 178478601HCID 178478601, compound

Procedure

A methanolic solution of the product prepared in Step A was diluted to 100 ml and 12.4 ml of concentrated HCl was added. The solution was stirred at ambient temperature for 18 hours, concentrated, and the residue was dissolve in 80 ml of water and extracted twice with CH2Cl2. The aqueous layer was concentrated, treated with n-propanol and concentrated under high vacuum to give the title compound as a foam.

Workup

  1. additionwas added
  2. concentrationconcentrated
  3. dissolutionthe residue was dissolve in 80 ml of water
  4. extractionextracted twice with CH2Cl2
  5. concentrationThe aqueous layer was concentrated
  6. additiontreated with n-propanol
  7. concentrationconcentrated under high vacuum

Sources & evidence

ORD record
ord-fde8768227fe4844bf4a6aea2cdbdb77
Source dataset
uspto-grants-1985_07
Patent number
US04528375

Reaction notes

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