Hydrochloric Acid → HCID 178483273, compound

HRID 370829Notes

Reaction equation

HRID 370829 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]2[CH:16]=[C:15]([CH2:17][N:18]([CH3:20])[CH3:19])[S:14][CH:13]=2)=[N:5]S(=O)[N:3]=1.[ClH:22]>CO>[ClH:22].[ClH:22].[ClH:22].[CH3:20][N:18]([CH2:17][C:15]1[S:14][CH:13]=[C:12]([CH2:11][S:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])[CH:16]=1)[CH3:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23312529HCID 23312529, compound

Product 1

HCID 178483273HCID 178483273, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-amino-4-{2-[(5-dimethylaminomethyl-3-thienyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide (7.8 g; 22.6 mmoles) [prepared according to published United Kingdom Patent Application No. 2,067,987] in 150 ml of methanol was treated with 15.0 ml of concentrated HCl. After stirring at ambient temperature for 3 hours, the solution was concentrated and the residue triturated with 1-propanol, filtered and dried to give 7.38 g (80%) of product. A sample was recrystallized from methanol-acetone to give the title compound, mp 190°-205° C. (dec.).

Workup

  1. concentrationthe solution was concentrated
  2. customthe residue triturated with 1-propanol
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-a7e64e7e35cc48799e4a6df75cfb8a8a
Source dataset
uspto-grants-1985_07
Patent number
US04528378

Reaction notes

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