反应详情

A mixture of N-[1,1-dimethoxycarbonyl-4-oxo-4-(2-thienyl)butyl]-L-alanyl-L-proline t-butyl ester (Example 31; 1.5 g.) and trifluoroacetic acid (20 ml.) was kept at laboratory temperature for 2 hours and then evaporated to dryness under reduced pressure at less than 30° C., using toluene as described in Example 20. There was thus obtained as an oil N-[1,1-dimethoxycarbonyl-4-oxo-4-(2-thienyl)butyl]-L-alanyl-L-proline trifluoroacetate.

1. customevaporated to dryness under reduced pressure at less than 30° C.