HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 2-Amino-9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-9H-purine bis hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | (2R,3R,4R,5R)-5-(2-Amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol | HCID 10355712 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-9H-purine bis hydrochloride | HCID 86748688 | — |
Reaction Steps
To a solution of 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine (300 mg 1.11 mmol) in MeOH (20 ml) was added isopropanol (2.5 ml) previously saturated with hydrochloride (HCL) gas. Acetone (15 ml) was added and the solution evaporated to almost dryness under vacuum at room temperature. Trituration with ethyl acetate (15 ml) produced a white solid which was filtered and washed with ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420115 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-28097341039e4cbe8dc7d52b6100e3d6 |
| Source note | uspto-grants-1995_05 |