反应详情

To a solution of 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine (300 mg 1.11 mmol) in MeOH (20 ml) was added isopropanol (2.5 ml) previously saturated with hydrochloride (HCL) gas. Acetone (15 ml) was added and the solution evaporated to almost dryness under vacuum at room temperature. Trituration with ethyl acetate (15 ml) produced a white solid which was filtered and washed with ether.

1. customthe solution evaporated to almost dryness under vacuum at room temperature
2. customTrituration with ethyl acetate (15 ml) produced a white solid which
3. filtrationwas filtered
4. washwashed with ether