Hydrochloric Acid → (2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride

HRID 370882Notes

Reaction equation

HRID 370882 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:20])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=2[OH:19])[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[OH:19][C:12]1[CH:13]=[C:14]([O:17][CH3:18])[CH:15]=[CH:16][C:11]=1[C:10]([CH:7]1[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]1)=[O:20]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13180314HCID 13180314, compound

Product 1

HCID 13076391(2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride

Procedure

To a round-bottom flask, equipped with a condenser and mechanical stirrer, was added 25.0 g of 1-acetyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine and 148 ml of 6N hydrochloric acid. The reaction mixture was stirred under reflux for 6 hrs and overnight at ambient temperature. The precipitate was collected, washed with acetone and recrystallized twice from ethanol to yield 16.70 g of product, mp, 264°-266°.

Workup

  1. customTo a round-bottom flask, equipped with a condenser and mechanical stirrer
  2. customThe precipitate was collected
  3. washwashed with acetone
  4. customrecrystallized twice from ethanol

Sources & evidence

ORD record
ord-35c7a469b1f24cc9b5a963aa3f4cf018
Source dataset
uspto-grants-1985_07
Patent number
US04528376

Reaction notes

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