反应详情

N-Isopropyl 4-chlorobenzamide (12.7 g, 64.3 mmole) and thionyl chloride (53.81 g, 447 mmole) were heated at reflux with stirring for two hours. Excess thionyl chloride was removed by distillation. The title compound was isolated by distillation (b.p. 65°-70° C. at ~1 mm Hg) to yield 10.7 g (77%) of a light brown yellow liquid.

1. temperatureat reflux
2. customExcess thionyl chloride was removed by distillation