Dichloromethane → Methyl 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-oxopentanoate

HRID 371017Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 371017
[Cl:1][C:2]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:3]=1[O:4][C:5]1[CH:20]=[CH:19][C:8]([O:9][CH:10]([CH3:18])[C:11]([O:16]C)=[CH:12][C:13]([OH:15])=[O:14])=[CH:7][CH:6]=1.Cl(O)(=O)(=O)=O.[CH2:34](Cl)Cl>>[Cl:1][C:2]1[CH:24]=[C:23]([C:25]([F:27])([F:26])[F:28])[CH:22]=[CH:21][C:3]=1[O:4][C:5]1[CH:20]=[CH:19][C:8]([O:9][CH:10]([CH3:18])[C:11](=[O:16])[CH2:12][C:13]([O:15][CH3:34])=[O:14])=[CH:7][CH:6]=1

Komponenten

4

Edukt 3

HCID 6344DichloromethaneHCID 24247Perchloric AcidHCID 538603484-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid

Produkt 1

HCID 13576486Methyl 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-oxopentanoate

Versuchsvorschrift

A mixture of the methyl ester of 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid (0.5 g), 35% aqueous perchloric acid (5 ml.) and methylene dichloride (5 ml.) is stirred at RT for 4 days. Then the solution is extracted with methylene dichloride. The combined extracts are washed, dried and evaporated. The residue is purified by prep. thin layer chromatography using 20% ethyl acetate/hexane to yield methyl 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-oxopentanoate.

Aufarbeitung

  1. extractionThen the solution is extracted with methylene dichloride
  2. washThe combined extracts are washed
  3. customdried
  4. customevaporated
  5. customThe residue is purified by prep

Quellen und Nachweise

ORD-Eintrag
ord-5b65fa510eea42f085e632cbd326365c
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04529438

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