HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3,5-Dichloro-pyridin-2-yloxy)-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydroquinone | HCID 785 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Pyridine, 2,3,5-trichloro- | HCID 27666 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(3,5-Dichloro-pyridin-2-yloxy)-phenol | HCID 620880 | — |
Reaction Steps
A mixture of 2,3,5-trichloropyridine (2.5 g, 13.7 mm), hydroquinone (3.02 g, 27.4 mm), KOH (3.07 g, 54.8 mm) and DMSO (10 ml) is heated to 160° for 3 hours. The mixture is poured into water, acidified with dilute HCl and extracted with ether. The ethereal solution is washed, dried and evaporated to dryness. The crude product is chromatographed on silica gel to give crystalline 4-(3,5-dichloropyridyloxy)phenol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04529438 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-4f564ecb133e48fe8515d942dea3c6d6 |
| Source note | uspto-grants-1985_07 |