反应详情

A mixture of 2,3,5-trichloropyridine (2.5 g, 13.7 mm), hydroquinone (3.02 g, 27.4 mm), KOH (3.07 g, 54.8 mm) and DMSO (10 ml) is heated to 160° for 3 hours. The mixture is poured into water, acidified with dilute HCl and extracted with ether. The ethereal solution is washed, dried and evaporated to dryness. The crude product is chromatographed on silica gel to give crystalline 4-(3,5-dichloropyridyloxy)phenol.

1. temperatureis heated to 160° for 3 hours
2. extractionextracted with ether
3. washThe ethereal solution is washed
4. customdried
5. customevaporated to dryness
6. customThe crude product is chromatographed on silica gel