反应详情

50.0 g (0.344 mols) of 7-aminoheptanoic acid and 63.5 g (0.514 mol) of O-methylisourea sulfate were dissolved in 250 ml of 50% aqueous methanol (v/v). To the solution was added dropwise a solution of 34.3 g (0.858 mol) of sodium hdyroxide in 400 ml of water. Then, the mixture was heated overnight under reflux. The reaction mixture was concentrated to about a half volume under reduced pressure followed by cooling the concentrate to precipitate white crystals. The crystals were collected by filtration, and dried to give 42.6 g (yield: 66.1%) of 7-guanidinoheptanoic acid.

1. temperatureThen, the mixture was heated overnight
2. temperatureunder reflux
3. concentrationThe reaction mixture was concentrated to about a half volume under reduced pressure
4. temperatureby cooling the
5. concentrationconcentrate
6. customto precipitate white crystals
7. filtrationThe crystals were collected by filtration
8. customdried