Acetic Acid → HCID 178476622, compound

HRID 371077Notes

Reaction equation

HRID 371077 reaction equation
[NH:1]([CH2:5][CH2:6][CH2:7][CH2:8][C@H:9]([OH:14])[CH2:10][C:11]([OH:13])=[O:12])[C:2]([NH2:4])=[NH:3].Cl.[C:16](O)(=[O:18])[CH3:17]>>[NH:1]([CH2:5][CH2:6][CH2:7][CH2:8][C@H:9]([O:14][C:16](=[O:18])[CH3:17])[CH2:10][C:11]([OH:13])=[O:12])[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 178512823HCID 178512823, compound

Product 1

HCID 178476622HCID 178476622, compound

Procedure

3.55 g (14.8 mmols) of 7-guanidino-3(S)-hydroxyheptanoic acid was dissolved in 100 ml of glacial acetic acid, and hydrogen chloride gas was introduced to saturation at a temperature lower than room temperature. The reaction mixture was stirred for 2 hours at room temperature, and concentrated under reduced pressure. The above procedure was carried out two more times, and the residue was sufficiently dried to obtain the desired product in a quantitative yield.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customthe residue was sufficiently dried

Sources & evidence

ORD record
ord-c1f033a4473e4131b32ce339d7d1096c
Source dataset
uspto-grants-1985_07
Patent number
US04529549

Reaction notes

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