Water → 1-Ethoxycarbonyl-4-benzyloxypiperidine

HRID 371088Notes

Reaction equation

HRID 371088 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].Cl.[CH2:8]([O:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C([O-])([O-])=O.[K+].[K+].O>C(Cl)(Cl)Cl>[CH2:5]([O:4][C:2]([N:19]1[CH2:18][CH2:17][CH:16]([O:15][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:21][CH2:20]1)=[O:3])[CH3:6]

Participants

6

Reactant 4

HCID 962WaterHCID 10928Ethyl chloroformateHCID 11430Potassium CarbonateHCID 128070004-(Benzyloxy)piperidine hydrochloride

Product 1

HCID 127964251-Ethoxycarbonyl-4-benzyloxypiperidine

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

3,4 g (0.033 mol) of ethyl chloroformate are added dropwise to a stirred mixture of 6.83 g (0.03 mol) of 4-benzyloxypiperidine hydrochloride, 7.74 g (0.056 mol) of dry K2CO3, 26 ml of water and 26 ml of chloroform. After stirring for 1 hour, the organic phase is decanted after dilution with 54 ml of chloroform, and washed 3 times with 20 ml of water and dried (MgSO4). Evaporation of the solvent in vacuo gives a liquid, which is distilled in vacuo.

Workup

  1. customthe organic phase is decanted after dilution with 54 ml of chloroform
  2. washwashed 3 times with 20 ml of water
  3. dry with materialdried (MgSO4)
  4. customEvaporation of the solvent in vacuo
  5. customgives a liquid, which
  6. distillationis distilled in vacuo

Sources & evidence

ORD record
ord-e7aae70cb89b4d888e916d260994d28b
Source dataset
uspto-grants-1985_07
Patent number
US04529730

Reaction notes

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