反应详情

To a solution of 7.5 g of 4-(4-biphenylyl)-4-oxobutyric acid in 40 ml of chloroform and 3.4 g of triethylamine is added a solution of 6.2 g of 3-bromophthalide in 20 ml of chloroform. The solution thus obtained is stirred 24 hours at room temperature, the organic phase is washed with an aqueous solution of sodium bicarbonate, then with water and finally it is dried on anhydrous sodium sulfate and evaporated to dryness to give the phthalidyl 4-(4-biphenylyl)-4-oxobutyrate; yield 73%.

1. customThe solution thus obtained
2. washthe organic phase is washed with an aqueous solution of sodium bicarbonate
3. dry with materialwith water and finally it is dried on anhydrous sodium sulfate
4. customevaporated to dryness