3-(Trifluoromethyl)aniline → 1-Methyl-3-[3-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione

HRID 371130Notes

Reaction equation

N[C:2]1[CH:3]=[C:4]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:6][CH:7]=1.[CH3:12][N:13]1[C:17](=[O:18])[CH:16]=[CH:15][C:14]1=[O:19]>>[F:9][C:8]([F:11])([F:10])[C:4]1[CH:3]=[C:2]([C:15]2[C:14]([N:13]([CH3:12])[C:17](=[O:18])[CH:16]=2)=[O:19])[CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 73753-(Trifluoromethyl)aniline

HCID 70261N-Methylmaleimide

Product 1

HCID 202744061-Methyl-3-[3-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione

Procedure

An 80.6 g portion of 3-aminobenzotrifluoride was reacted with 55.6 g of N-methylmaleimide as described in Example 6, giving 2-(m-trifluoromethylphenyl)-N-methylmaleimide.

Sources & evidence

ORD record: ord-4d55922743f24e3a8745ea3750ec8fc2
Source dataset: uspto-grants-1985_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04529736

Reaction notes

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