Hydrochloric Acid → HCID 13519549, compound

HRID 371145Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH:17]4[CH2:18][CH:14]([CH2:15][CH2:16]4)[CH:13]2[CH2:12][N:11](C(OCC)=O)[CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH:17]4[CH2:18][CH:14]([CH2:15][CH2:16]4)[CH:13]2[CH2:12][NH:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86740198HCID 86740198, compound

Product 1

HCID 13519549HCID 13519549, compound

Procedure

By the method of Example 26, (-)-3a-(3,4-dichlorophenyl)octahydro-2-methyl-4,7-methano-1H-isoindole is reacted with ethyl chloroformate in toluene to give the corresponding 3a-(3,4-dichlorophenyl)octahydro-4,7-methano-2H-isoindole-2-carboxylic acid, ethyl ester. This urethane is hydrolyzed with hydrochloric acid and the solution is evaporated to give (-)-3a-(3,4-dichlorophenyl)octahydro-4,7-methano-1H-isoindole hydrochloride as colorless crystals.

Workup

customthe solution is evaporated

Sources & evidence

ORD record: ord-8884d0bec0554654a9646d23fa1aab0e
Source dataset: uspto-grants-1985_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04529736

Reaction notes

Loading…