Methanol → HCID 131714282, compound

HRID 371269Notes

Reaction equation

HRID 371269 reaction equation
CO.[CH2:3]([O:6][C:7]([CH2:9][N:10]1[C@H:13]([S:14]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[C@@H:12]([CH:34]([OH:36])[CH3:35])[C:11]1=[O:37])=[O:8])[CH:4]=[CH2:5].[N+]([O-])([O-])=O.[Ag+:42]>N1C=CC=CC=1>[OH:36][CH:34]([C@@H:12]1[C@@H:13]([S-:14])[N:10]([CH2:9][C:7]([O:6][CH2:3][CH:4]=[CH2:5])=[O:8])[C:11]1=[O:37])[CH3:35].[Ag+:42]

Participants

5

Reactant 3

HCID 887MethanolHCID 24470Silver NitrateHCID 13303848HCID 13303848, compound

Product 1

HCID 131714282HCID 131714282, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
20 °C

Procedure

To a 50 ml flask equipped with a nitrogen atmosphere add 10 ml of methanol and 460 mg of (3S,4R)-1-(allyloxycarbonylmethyl)-3-(1-hydroxyethyl)-4-(triphenylmethylthio)azetidin-2-one. To this system add 160 mg silver nitrate and 0.15 ml of pyridine. Stir the system at 20° C. for 1 hour. Stop the reaction and remove the methanol by stripping to give the title compound.

Workup

  1. customTo a 50 ml flask equipped with a nitrogen atmosphere
  2. customthe reaction
  3. customremove the methanol

Sources & evidence

ORD record
ord-642b7ea79c7542e5acad79d1b53e00b8
Source dataset
uspto-grants-1985_07
Patent number
US04530793

Reaction notes

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