Phosgene → HCID 13720696, compound

HRID 371331Notes

Reaction equation

HRID 371331 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[C:12](Cl)([Cl:14])=[O:13]>C(Cl)Cl>[N:10]1[C:11]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[NH:1][C:12]([Cl:14])=[O:13])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 113598-Aminoquinoline

Product 1

HCID 13720696HCID 13720696, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

8-Aminoquinoline (2.0 g., Pfaltz & Bauer, A28560) in methylene chloride (10 ml) was added dropwise to a 0° C. solution of 2.2M phosgene in methylene chloride (12 ml). The resulting precipitate was filtered and dried. The dark solid thus obtained is unstable and in practice it was immediately used in the next reaction.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. customdried
  3. customThe dark solid thus obtained
  4. customwas immediately used in the next reaction

Sources & evidence

ORD record
ord-dc6bfa4b738245a2b3ec7f3564126b2c
Source dataset
uspto-grants-1985_07
Patent number
US04530931

Reaction notes

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