Propargyl bromide → HCID 11228839, compound

In a mixture of propargyl bromide (3.46 g, 29 mmol), zinc powder (2.3 g, 0.035 gram-atom) in tetrahydrofuran (60 ml), trifluoroacetaldehyde (1.9 g, 19 mmol) was added under bubbling. An hour later, the reaction mixture was poured into aqueous 2% HCl solution for a similar treatment to the one used in the above Examples. Distillation gave 1,1,1-trifluoro-4-pentyne-2-ol (b.p.: 95°-96° C.) at a yield of 65%. The above product gave the following analytical data:

1. additionwas added
2. customunder bubbling
3. additionAn hour later, the reaction mixture was poured into aqueous 2% HCl solution for a similar treatment to the one
4. distillationDistillation

ORD record

ord-8773d4229dae418ab413837f4e302b9b

Source dataset

uspto-grants-1985_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04532020