Hydrochloric Acid → HCID 178524699, compound

HRID 37137Notes

Reaction equation

HRID 37137 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:16]=[CH:15][C:14]([S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:13][CH:12]=3)=[C:6]2[N:5]=[CH:4][C:3]=1[C:24]([O:26]CC)=[O:25].[OH-].[Na+].C(O)C.Cl>O>[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:12]=[CH:13][C:14]([S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:15][CH:16]=3)=[C:6]2[N:5]=[CH:4][C:3]=1[C:24]([OH:26])=[O:25]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 178469484HCID 178469484, compound

Product 1

HCID 178524699HCID 178524699, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 10.30 g of 7-hydroxy-6-ethoxycarbonyl-3-(4-phenylthiophenyl)pyrazolo[1,5-a]pyrimidine, 6.59 g of sodium hydroxide, 300 ml of ethanol and 300 ml of water was heated and stirred for 2 hours. To the reaction mixture, 400 ml of water was added, and hydrochloric acid was also added while ice-cooling to adjust the pH to 1 to 2, and after stirring for 30 minutes, the precipitate was filtered, washed in water, and dried, thereby obtaining the title compound (9.42 g ).

Workup

  1. temperaturewas heated
  2. temperaturecooling
  3. stirringafter stirring for 30 minutes
  4. filtrationthe precipitate was filtered
  5. washwashed in water
  6. customdried

Sources & evidence

ORD record
ord-df8194254a9c457d9d5639b8b1ab4161
Source dataset
uspto-grants-1995_05
Patent number
US05420128

Reaction notes

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