反应详情

A mixture of 10.30 g of 7-hydroxy-6-ethoxycarbonyl-3-(4-phenylthiophenyl)pyrazolo[1,5-a]pyrimidine, 6.59 g of sodium hydroxide, 300 ml of ethanol and 300 ml of water was heated and stirred for 2 hours. To the reaction mixture, 400 ml of water was added, and hydrochloric acid was also added while ice-cooling to adjust the pH to 1 to 2, and after stirring for 30 minutes, the precipitate was filtered, washed in water, and dried, thereby obtaining the title compound (9.42 g ).

1. temperaturewas heated
2. temperaturecooling
3. stirringafter stirring for 30 minutes
4. filtrationthe precipitate was filtered
5. washwashed in water
6. customdried