反应详情

A mixture of 7.0 g (0.037 mole) of 4-chloro-6-hydrazino-2-methylthiopyrimidine and 100 ml of triethyl orthoformate was heated at reflux for 48 hours. Cooling provided a precipitate which was isolated by filtration, and then recrystallized from an ethanol-heptane mixture, with treatment with decolorizing charcoal. The product was red crystals of 7-chloro-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine, m.p. 164°-165° C.

1. temperaturewas heated
2. temperatureat reflux for 48 hours
3. temperatureCooling
4. customprovided a precipitate which
5. customwas isolated by filtration
6. customrecrystallized from an ethanol-heptane mixture, with treatment with decolorizing charcoal