HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → 7-Chloro-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 4-Chloro-6-hydrazinyl-2-(methylsulfanyl)pyrimidine | HCID 1484546 | — |
| Product | 7-Chloro-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine | HCID 13519858 | — |
Reaction Steps
A mixture of 7.0 g (0.037 mole) of 4-chloro-6-hydrazino-2-methylthiopyrimidine and 100 ml of triethyl orthoformate was heated at reflux for 48 hours. Cooling provided a precipitate which was isolated by filtration, and then recrystallized from an ethanol-heptane mixture, with treatment with decolorizing charcoal. The product was red crystals of 7-chloro-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine, m.p. 164°-165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04532242 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-2132604681b044c0af377e7cdc2929c9 |
| Source note | uspto-grants-1985_07 |