Hydrochloric Acid → HCID 178521928, compound

HRID 37139Notes

Reaction equation

HRID 37139 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:16]=[CH:15][C:14]([S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:13][CH:12]=3)=[C:6]2[N:5]=[CH:4][C:3]=1[C:24](OCC)=[O:25].Cl.[NH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:12]=[CH:13][C:14]([S:17][C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)=[CH:15][CH:16]=3)=[C:6]2[N:5]=[CH:4][C:3]=1[C:24](=[O:25])[NH:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 178469484HCID 178469484, compound

Product 1

HCID 178521928HCID 178521928, compound

Conditions

Temperature
180 °C

Procedure

Dissolving 280 mg of 7-hydroxy-6-ethoxycarbonyl-3-(4-phenylthiophenyl)pyrazolo[1,5-a]pyrimidine in 3 ml of aniline, the mixture was stirred for 3 hours at 180° C. After allowing to cool, 10% hydrochloric acid was added, the precipitate was filtered, washed with water and dried, and the title compound was obtained (220 mg, 68%).

Workup

  1. temperatureto cool
  2. filtrationthe precipitate was filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-690b27a5b65a40d1ac774e79ad21b3d0
Source dataset
uspto-grants-1995_05
Patent number
US05420128

Reaction notes

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