反应详情

温度

20 °C

A mixture of 72 g (0.28 mole) of 2-benzylthio-4-hydroxy-6-n-propylpyrimidine (from Part A) and 100 ml of phosphorus oxychloride was heated at reflux for three hours, and was then allowed to cool to 20° C. After evaporating in vacuo the residue was poured into ice water with vigorous stirring. The mixture was extracted with three 75 ml portions of diethyl ether, and the extracts were dried over magnesium sulfate and evaporated to provide a yellow oil residue of 2-benzylthio-4-chloro-6-n-propylpyrimidine.

1. temperaturewas heated
2. temperatureat reflux for three hours
3. customAfter evaporating in vacuo the residue
4. additionwas poured into ice water with vigorous stirring
5. extractionThe mixture was extracted with three 75 ml portions of diethyl ether
6. dry with materialthe extracts were dried over magnesium sulfate
7. customevaporated