反应详情

温度

80 °C

A mixture of 9.32 g of 7-hydroxy-6-carboxy-3-(4-phenylthiophenyl)pyrazolo[1,5-a]pyrimidine and 68 ml of aniline was heated and stirred at 80° C. for 1.5 hours to react. To the reaction mixture, 300 ml of water was added, and while ice-cooling, hydrochloric acid was added to adjust the pH to 1 to 2. Adding 100 ml of methanol, the mixture was stirred for 30 minutes while ice-cooling, and the precipitate was filtered, washed in cold water-methanol (3:1), and dried, and the title compound was obtained (8.17 g).

1. temperaturewas heated
2. customto react
3. temperaturewhile ice-cooling
4. stirringthe mixture was stirred for 30 minutes while ice-
5. temperaturecooling
6. filtrationthe precipitate was filtered
7. washwashed in cold water-methanol (3:1)
8. customdried