Sulfuric Acid → 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)pyridine

HRID 371416Notes

Reaction equation

HRID 371416 reaction equation
S(=O)(=O)(O)O.[CH3:6][C:7]1[NH:8][C:9]([CH3:29])=[C:10](C(O)=O)[CH:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]([F:25])([F:24])[F:23])[C:12]=1[N+:13]([O-:15])=[O:14]>C(O)C>[CH3:6][C:7]1[NH:8][C:9]([CH3:29])=[CH:10][CH:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]([F:24])([F:23])[F:25])[C:12]=1[N+:13]([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 131211931,4-Dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)-pyridine-5-carboxylic acid

Product 1

HCID 131211941,4-Dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)pyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

On heating in ethanol with the addition of a trace of sulphuric acid, 1,4-dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)-pyridine-5-carboxylic acid (obtained as described in Example 30) was decarboxylated to give 1,4-dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)pyridine in quantitative yield. Melting point 201° C.

Sources & evidence

ORD record
ord-d575c32824e34cd4962d34c9f11424fc
Source dataset
uspto-grants-1985_07
Patent number
US04532248

Reaction notes

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