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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 371416Generated: October 27, 2026

Sulfuric Acid → 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)pyridine

https://huagongshe.com/reaction/371416

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSulfuric AcidHCID 1118—
Reactant1,4-Dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)-pyridine-5-carboxylic acidHCID 13121193—
SolventEthanolHCID 702—
Product1,4-Dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)pyridineHCID 13121194—

Reaction Steps

On heating in ethanol with the addition of a trace of sulphuric acid, 1,4-dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)-pyridine-5-carboxylic acid (obtained as described in Example 30) was decarboxylated to give 1,4-dihydro-2,6-dimethyl-3-nitro-4-(trifluoromethylphenyl)pyridine in quantitative yield. Melting point 201° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04532248
Source datasetuspto-grants-1985_07
ORD IDord-d575c32824e34cd4962d34c9f11424fc
Source noteuspto-grants-1985_07