1-Phenylpiperazine → 6-Methyl-5-(4-phenyl-1-piperazinyl)-2,4(1H, 3H)-pyrimidinedione, hydrate

Participants

Reaction Steps

A mixture of 20.5 g (0.10 mole) of 5-bromo-6-methyl-2,4(1H, 3H)-pyrimidinedione and 10.3 g (0.11 mole) of potassium fluoride dihydrate in 150 ml of 1-phenylpiperazine was heated under reflux at 105° for 72 hours and cooled. The reaction mixture was poured into 200 ml of ice water. The solid was collected, washed with water, and recrystallized from methanol to give 7.12 g of the product as a white solid, mp>300° C.

Provenance & Evidence