反应详情

A mixture of 20.5 g (0.10 mole) of 5-bromo-6-methyl-2,4(1H, 3H)-pyrimidinedione and 10.3 g (0.11 mole) of potassium fluoride dihydrate in 150 ml of 1-phenylpiperazine was heated under reflux at 105° for 72 hours and cooled. The reaction mixture was poured into 200 ml of ice water. The solid was collected, washed with water, and recrystallized from methanol to give 7.12 g of the product as a white solid, mp>300° C.

1. temperaturewas heated
2. temperatureunder reflux at 105° for 72 hours
3. temperaturecooled
4. customThe solid was collected
5. washwashed with water
6. customrecrystallized from methanol