Ethanol → HCID 178481764, compound

HRID 371610Notes

Reaction equation

HRID 371610 reaction equation
C[N:2]1[C:6]([N:7]=[CH:8]OCC)=[C:5]([C:12]#[N:13])[CH:4]=[N:3]1.O.[NH2:15][NH2:16].[CH2:17](O)C>>[CH3:17][N:15]1[C:12]2[N:13]=[CH:8][NH:7][C:6](=[N:2][NH2:3])[C:5]=2[CH:4]=[N:16]1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 242634Ethyl N-(4-cyano-1-methyl-1H-pyrazol-5-yl)methanimidate

Product 1

HCID 178481764HCID 178481764, compound

Procedure

160 g. of 1-methyl-4-cyano-5-ethoxymethyleneaminopyrazole are dissolved in 1 liter of absolute ethanol and 76.0 g. of hydrazine hydrate are added dropwise with stirring. This mixture is refluxed for 8 hours. After cooling, the product, 1,5-dihydro-1-methyl-4H-pyrazolo-[3,4-d]pyrimidin-4-one hydrazone, is filtered under suction and crystallized from dimethylformamide, yield 135 g., m.p. 231°.

Workup

  1. temperatureThis mixture is refluxed for 8 hours
  2. temperatureAfter cooling
  3. filtrationthe product, 1,5-dihydro-1-methyl-4H-pyrazolo-[3,4-d]pyrimidin-4-one hydrazone, is filtered under suction
  4. customcrystallized from dimethylformamide, yield 135 g

Sources & evidence

ORD record
ord-1a26e02c46e742b7ad17418ad1ec8290
Source dataset
uspto-grants-1978_05
Patent number
US04087423

Reaction notes

Loading…