Methyl iodide → HCID 20355373, compound

HRID 371611Notes

Reaction equation

HRID 371611 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]3[C:11]([SH:14])=[N:12][N:13]=[C:6]3[C:5]=2[CH:4]=[N:3]1.[K].[CH3:16]I>CN(C)C=O>[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]3[C:11]([S:14][CH3:16])=[N:12][N:13]=[C:6]3[C:5]=2[CH:4]=[N:3]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 5462222PotassiumHCID 178481724HCID 178481724, compound

Product 1

HCID 20355373HCID 20355373, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 3 g. of 7-methyl-3mercapto-7H-pyrazolo[4,3-e][1,2,4]-triazolo[4,3-c]pyrimidine, potassium salt, in 25 ml. of dimethylformamide, 2.1 g. of methyl iodide are added and the mixture is stirred for 1 hour at room temperature. The reaction mixture is then poured into 200 ml. of water and the product, 7-methyl-3-methylthio-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]-pyrimidine, is filtered under suction, crystallized from dimethylformamide and obtained as yellowish crystals, m.p. 204°-206°.

Workup

  1. additionThe reaction mixture is then poured into 200 ml
  2. filtrationof water and the product, 7-methyl-3-methylthio-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]-pyrimidine, is filtered under suction
  3. customcrystallized from dimethylformamide
  4. customobtained as yellowish crystals, m.p. 204°-206°

Sources & evidence

ORD record
ord-5682143b98c64de0b513f48dfcf86ef2
Source dataset
uspto-grants-1978_05
Patent number
US04087423

Reaction notes

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