Water → HCID 20355358, compound

HRID 371643Notes

Reaction equation

HRID 371643 reaction equation
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11]3=[CH:13][S:14][CH:15]=[C:10]3[C:9](SC)=[N:8][C:7]=2[CH:18]=1.O.[OH:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>C(O)(=O)C>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11]3=[CH:13][S:14][CH:15]=[C:10]3[C:9]([N:26]3[CH2:27][CH2:28][N:23]([CH2:22][CH2:21][OH:20])[CH2:24][CH2:25]3)=[N:8][C:7]=2[CH:18]=1

Participants

5

Reactant 3

HCID 962WaterHCID 76771-(2-Hydroxyethyl)piperazineHCID 20355346HCID 20355346, compound

Product 1

HCID 20355358HCID 20355358, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 7,10-bis(methylthio)-4H-thieno[3,4-b][1,5]benzodiazepine in excess N-(2-hydroxyethyl)-piperazine and glacial acetic acid is heated at 140°-160° C. for 2 days. The solution is poured into water and the product is collected.

Workup

  1. customthe product is collected

Sources & evidence

ORD record
ord-698537d82f57408eae944493af5d5929
Source dataset
uspto-grants-1978_05
Patent number
US04087421

Reaction notes

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