Water → HCID 20355353, compound

HRID 371644Notes

Reaction equation

HRID 371644 reaction equation
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]2[N:8]=[C:9](SC)[C:10]3[C:11](=[CH:13][S:14][CH:15]=3)[NH:12][C:6]=2[CH:5]=1)([O-:3])=[O:2].O.[CH2:21]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(O)(=O)C>[N+:1]([C:4]1[CH:19]=[CH:18][C:7]2[N:8]=[C:9]([N:31]3[CH2:32][CH2:33][N:28]([CH2:21][C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:29][CH2:30]3)[C:10]3[C:11](=[CH:13][S:14][CH:15]=3)[NH:12][C:6]=2[CH:5]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 962WaterHCID 759941-BenzylpiperazineHCID 20355322HCID 20355322, compound

Product 1

HCID 20355353HCID 20355353, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 6-nitro-10-(methylthio)-4H-thieno[3,4-b][1,5]benzodiazepine in excess N-benzylpiperazine and glacial acetic acid is heated at 140°-160° C. for 2 days. The solution is poured into water and the product is collected.

Workup

  1. customthe product is collected

Sources & evidence

ORD record
ord-d6895fde147a40409350b6a812bd52ee
Source dataset
uspto-grants-1978_05
Patent number
US04087421

Reaction notes

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