Water → HCID 12521677, compound

HRID 371647Notes

Reaction equation

HRID 371647 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8](SC)[C:9]3[C:10](=[CH:12][S:13][CH:14]=3)[NH:11][C:5]=2[CH:4]=1.O.[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8]([N:24]3[CH2:25][CH2:26][N:21]([CH3:20])[CH2:22][CH2:23]3)[C:9]3[C:10](=[CH:12][S:13][CH:14]=3)[NH:11][C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 962WaterHCID 531671-MethylpiperazineHCID 20355326HCID 20355326, compound

Product 1

HCID 12521677HCID 12521677, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 6-methoxy-10-(methylthio)-4H-thieno[3,4-b][1,5]benzodiazepine in excess N-methylpiperazine and glacial acetic acid is heated at reflux for 2 days. The solution is poured into water and the product is collected.

Workup

  1. temperatureat reflux for 2 days
  2. customthe product is collected

Sources & evidence

ORD record
ord-7a1bcd3493f74cb492b38a3a8c1926ab
Source dataset
uspto-grants-1978_05
Patent number
US04087421

Reaction notes

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