HuagongsheHuagongshe Chemistry Print Report · For research reference only
Amantadine → HCID 53941885, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Amantadine | HCID 2130 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 2-(Dimethoxyphosphoryl)acetic acid | HCID 189964 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 53941885 | HCID 53941885 | — |
Reaction Steps
Adamantylamine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide was added portionwise. The solution was stirred overnight, and the mixture filtered. The filtrate was concentrated to a solid. It was recrystallized from an appropriate solvent such as methanol. m.p. 190°-4° C.; yield, 32%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04087522 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-9a8e205786444e46bdd7c9cade08ae9e |
| Source note | uspto-grants-1978_05 |