Hydrochloric Acid → HCID 20356205, compound

Participants

Reaction Steps

In an analogous manner as described in Example 7, 1-aminomethyl-1-cycloheptane-acetic acid hydrochloride is esterified with n-butanol in the presence of hydrogen chloride to give n-butyl 1-aminomethyl-1-cycloheptane-acetate hydrochloride in the form of a syrup, which is mixed with benzene and an equivalent amount of p-toluene-sulfonic acid. The mixture is evaporated in a vacuum to dryness. After crystallisation from chloroform/ether/hexane n-butyl 1-aminomethyl-1-cycloheptane-acetate .p-toluene-sulfonate is obtained. m.p. 116° - 118° C.

Provenance & Evidence