Hydrochloric Acid → HCID 20356205, compound

HRID 371729Notes

Reaction equation

HRID 371729 reaction equation
[ClH:1].[NH2:2][CH2:3][C:4]1([CH2:11][C:12]([OH:14])=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.Cl>C(O)CCC>[ClH:1].[NH2:2][CH2:3][C:4]1([CH2:11][C:12]([O:14][CH2:3][CH2:4][CH2:5][CH3:6])=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2132113260142-97-4

Product 1

HCID 20356205HCID 20356205, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In an analogous manner as described in Example 7, 1-aminomethyl-1-cycloheptane-acetic acid hydrochloride is esterified with n-butanol in the presence of hydrogen chloride to give n-butyl 1-aminomethyl-1-cycloheptane-acetate hydrochloride in the form of a syrup, which is mixed with benzene and an equivalent amount of p-toluene-sulfonic acid. The mixture is evaporated in a vacuum to dryness. After crystallisation from chloroform/ether/hexane n-butyl 1-aminomethyl-1-cycloheptane-acetate .p-toluene-sulfonate is obtained. m.p. 116° - 118° C.

Sources & evidence

ORD record
ord-7bfdd19a4cf9475a9a2077ce984094fd
Source dataset
uspto-grants-1978_05
Patent number
US04087544

Reaction notes

Loading…