Methanol → HCID 178465180, compound

HRID 371806Notes

Reaction equation

HRID 371806 reaction equation
[ClH:1].C(OC([NH:12][C@H:13]([C:21]([N:23]1[CH2:32][CH2:31][CH2:30][C@H:24]1[C:25]([N-:27][CH2:28][CH3:29])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:20])[NH2:19])=O)C1C=CC=CC=1.CO.[H][H]>[Pd].O>[ClH:1].[NH2:12][C@H:13]([C:21]([N:23]1[CH2:32][CH2:31][CH2:30][C@H:24]1[C:25]([N-:27][CH2:28][CH3:29])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:19])[NH2:20]

Participants

6

Reactant 3

HCID 887MethanolHCID 178418361HCID 178418361, compoundHCID 178465167HCID 178465167, compound

Product 1

HCID 178465180HCID 178465180, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

L-Arginyl-L-prolyl-N-ethylamide, hydrochloride is prepared by the following procedure. A solution of 8.7 g. of Nα -benzyloxycarbonyl-L-arginyl-L-prolyl-N-ethylamide hydrochloride in 100 ml. of methanol is stirred with 500 mg. of 20% palladium-on-carbon under one inch water pressure of hydrogen for three hours. The catalyst is removed by filtration and the filtrate evaporated under reduced pressure and at 35°-40° C. The residual foam is used without further purification.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe filtrate evaporated under reduced pressure and at 35°-40° C
  3. customThe residual foam is used without further purification

Sources & evidence

ORD record
ord-b8a06ddd38c6461aa1c1745defecf7d5
Source dataset
uspto-grants-1978_05
Patent number
US04087418

Reaction notes

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