Methanol → HCID 178465180, compound

Participants

Reaction Steps

L-Arginyl-L-prolyl-N-ethylamide, hydrochloride is prepared by the following procedure. A solution of 8.7 g. of Nα -benzyloxycarbonyl-L-arginyl-L-prolyl-N-ethylamide hydrochloride in 100 ml. of methanol is stirred with 500 mg. of 20% palladium-on-carbon under one inch water pressure of hydrogen for three hours. The catalyst is removed by filtration and the filtrate evaporated under reduced pressure and at 35°-40° C. The residual foam is used without further purification.

Provenance & Evidence