反应详情

Under a nitrogen atmosphere, heat at reflux for 3 hours, in the presence of 5 mmol of lithium aluminium hydride, a solution of 2 mmol of 6-hydroxy-2-{4-[bis-(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-1,4-benzodioxin in 35 cm3 of diethyl ether. After cooling, hydrolysis, removal of the insoluble mineral compounds by filtration and drying over magnesium sulfate, the compound obtained is purified by chromatography on a column of silica (eluant:petroleum ether/ethyl acetate, 40:60). 6-Hydroxy-2-{4-[bis-(4-fluorophenyl)methyl]piperazin -1-ylmethyl}-1,4-benzodioxin is thereby obtained in a yield of 85%.

1. temperatureUnder a nitrogen atmosphere, heat
2. temperatureAfter cooling
3. customhydrolysis, removal of the insoluble mineral compounds
4. filtrationby filtration
5. dry with materialdrying over magnesium sulfate
6. customthe compound obtained
7. customis purified by chromatography on a column of silica (eluant:petroleum ether/ethyl acetate, 40:60)